| Identification | Back Directory | [Name]
1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]- | [CAS]
1424635-83-5 | [Synonyms]
TRULI
Lats-IN-1
Lats-IN-1(TRULI )
1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]- | [Molecular Formula]
C18H14N4OS | [MDL Number]
MFCD33402276 | [MOL File]
1424635-83-5.mol | [Molecular Weight]
334.39 |
| Chemical Properties | Back Directory | [density ]
1.36±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 83.33 mg/mL (249.20 mM) | [form ]
A solid | [pka]
12.30±0.40(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Biological Activity]
TRULI is a call penetrantpotent and non-toxic activator of Yap signaling. TRULI is an ATP-competitive inhibitor of Lats kinases (the core enzymes in Hippo signaling) th at induces robust Yap nuclear translocation and prevents Yap phosphorylation. TRULI induces proliferation of supporting cells in the murine inner earmurine cardiomyocytesand human Müller glia in retinal organoids. |
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