| Chemical Properties | Back Directory | [Boiling point ]
533.3±60.0 °C(Predicted) | [density ]
1.63±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
3.79±0.50(Predicted) | [color ]
Off-white to yellow |
| Hazard Information | Back Directory | [Description]
EHT-5372 is a potent and selective DYRK1A inhibitor (IC50 = 0.22 nM). EHT-5372 shows high degree of selectivity over 339 kinases. EHT 5372 inhibits DYRK1A-induced Tau phosphorylation at multiple AD-relevant sites in biochemical and cellular assays. EHT 5372 also normalizes both Aβ-induced Tau phosphorylation and DYRK1A-stimulated Aβ production. EHT 5372 inhibits DYRK1A-induced Tau phosphorylation, Aβ production and Aβ effects on phospho-Tau, including Tau aggregation. |
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