| Identification | Back Directory | [Name]
(2S,6S)-2-AMINO-2-(2-CHLOROPHENYL)-6-HYDROXYCYCLOHEXAN-1-ONE HCL | [CAS]
1430202-70-2 | [Synonyms]
(2S,6S)-Hydroxynorketamine
2S,6S-Hydroxynorketamine hydrochloride
(2S,6S)-Hydroxynorketamine hydrochloride >=98% (HPLC)
(2S,6S)-2-AMINO-2-(2-CHLOROPHENYL)-6-HYDROXYCYCLOHEXAN-1-ONE HCL
(2S,6S)-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride
(2S,6S)-2-amino-2-(2-chlorophenyl)-6-hydroxycyclohexan-1-onehydrochloride | [Molecular Formula]
C12H15Cl2NO2 | [MDL Number]
MFCD30720898 | [MOL File]
1430202-70-2.mol | [Molecular Weight]
276.159 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
Soluble to 50 mM in water and to 100 mM in DMSO | [form ]
powder | [color ]
white to beige | [optical activity]
[α]/D +95 to +115°, c = 1 in H2O |
| Hazard Information | Back Directory | [Uses]
2S,6S-Hydroxynorketamine Hydrochloride is a compound used in the treatment of neurological disorders such as depression, anxiety and various phobias involving social interaction. N-methyl-D-apartate receptor antagonist. Antidepressant. | [Biochem/physiol Actions]
(2S,6S)-Hydroxynorketamine hydrochlorideKetamine is a metabolite associated with increased locomotor activity and motor incoordination.It has been found that the NMDAR antagonist (R,S)-ketamine must be metabolized to (2S,6S;2R,6R)-hydroxynorketamine (HNK) to have antidepressant effects. The (2R,6R)-HNK enantiomer appears to be the enantiomer most responsible for antidepressant effects, while (2S,6S)-hydroxynorketamine was associated with increased locomotor activity and motor incoordination. (2S,6S)-HNK, was also found to increase the function of the mammalian target of rapamycin (mTOR) 2-fold at 0.05 nM. (2S,6S)-HNK and (2R,6R)-HNK both inhibited intracellular concentrations of D-serine, an endogenous NMDA receptor co-agonist, with IC50 values of 0.18 nM and 0.68 nM, respectively. Neither bind with high affinity to NMDA receptors, with Ki values of 21.19 μM and > 100 μM for (2S,6S)-HNK and (2R,6R)-HNK, respectively. | [storage]
Store at RT |
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