| Chemical Properties | Back Directory | [Boiling point ]
845.2±65.0 °C(Predicted) | [density ]
1.256±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C, protect from light | [solubility ]
DMSO: soluble | [form ]
A solid | [pka]
12.57±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Ac-PAL-AMC is a fluorogenic substrate for the β1i/LMP2 subunit of the 20S immunoproteasome.1,2 Upon cleavage, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify the activity of the β1i/LMP2 subunit of the 20S immunoproteasome. Ac-PAL-AMC is selective for the immunoproteasome over the constitutive proteasome. AMC displays excitation/emission maxima of 351/430 nm, respectively. | [storage]
Store at -20°C, protect from light | [References]
1. Blackburn, C., Gigstad, K.M., Hales, P., et al. Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S β5-subunit Biochem. J. 430(3),461-476(2010).
2. Park, J.E., Ao, L., Miller, Z., et al. PSMB9 codon 60 polymorphisms have no impact on the activity of the immunoproteasome catalytic subunit B1i expressed in multiple types of solid cancer PLoS One 8(9),e73732(2013). |
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