ChemicalBook--->CAS DataBase List--->1431698-47-3

1431698-47-3

1431698-47-3 Structure

1431698-47-3 Structure
IdentificationBack Directory
[Name]

KN-92 (hydrochloride)
[CAS]

1431698-47-3
[Synonyms]

CS-1448
KN92-HCl
KN-92 (hydrochloride)
KN 92 HYDROCHLORIDE; KN92 HYDROCHLORIDE
[Molecular Formula]

C24H26Cl2N2O3S
[MDL Number]

MFCD25372041
[MOL File]

1431698-47-3.mol
[Molecular Weight]

493.446
Chemical PropertiesBack Directory
[storage temp. ]

Inert atmosphere,Store in freezer, under -20°C
[solubility ]

≥24.65 mg/mL in DMSO; insoluble in H2O; ≥11.73 mg/mL in EtOH with gentle warming and ultrasonic
[form ]

solid
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501
Spectrum DetailBack Directory
[Spectrum Detail]

KN-92 (hydrochloride)(1431698-47-3)1HNMR
Hazard InformationBack Directory
[Biological Activity]

kn-92 is an inactive analog of kn-93. kn-93 is the cam kinase ii inhibitor. [1]hearts were treated with the cam kinase inhibitor kn-93 or the inactive analog kn-92 (0.5 μm) for 10 min before clofilium exposure. early afterdepolarizations (eads) were largely inhibited by kn-93 contrasted to kn-92. there were little differences in parameters favoring eads such as monophasic action potential duration or heart rate in kn-92- or kn-93- treated hearts. cam kinase activity in situ increased 37% in hearts with eads compared to hearts without eads. this increase in cam kinase activity was prevented by pretreatment with kn-93. [1]in vitro, kn-93 potently suppressed rabbit myocardial cam kinase activity (calculated ki ≤ 2.58 μm), but the inactive analog kn-92 did not (ki > 100 μm). the actions of kn-93 and kn-92 on ica and other repolarizing k+currents did not illustrate preferential ead suppression by kn-93. [1]
[References]

1. kn-93, an inhibitor of multifunctional ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. j pharmacol exp ther. 1998 dec;287(3):996-1006.
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