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143292-98-2

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143292-98-2 Structure

143292-98-2 Structure
IdentificationBack Directory
[Name]

5(S)-HPEPE
[CAS]

143292-98-2
[Synonyms]

5(S)-HPEPE
5(S)HpEPE,5(S) HpEPE
NKXYOIJDQPQELO-GHWNLOBHSA-N
5S-HYDROPEROXY-6E,8Z,11Z,14Z,17Z-EICOSAPENTAENOIC ACID
6,8,11,14,17-Eicosapentaenoic acid, 5-hydroperoxy-, [S-(E,Z,Z,Z,Z)]- (9CI)
[Molecular Formula]

C20H30O4
[MDL Number]

MFCD00065834
[MOL File]

143292-98-2.mol
[Molecular Weight]

334.45
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml
Safety DataBack Directory
[Symbol(GHS) ]


GHS02
[Signal word ]

Danger
Hazard InformationBack Directory
[Description]

5(S)-HpEPE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 5-LO on EPA.1 It is metabolized to LTA5, a key intermediate in the formation of the 5-series leukotrienes. Alternatively, 5(S)-HpEPE is reduced to 5(S)-HEPE by peroxidases.
[Definition]

ChEBI: 5S-HpEPE is a HPETE.
[References]

1. Kulkarni, P.S., Kaufman, P.L., and Srinivasan, B.D. Eicosapentaenoic acid metabolism in cynomolgus and rhesus conjunctiva and eyelid J. Ocul. Pharmacol. 3(4),349-356(1987).
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