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1435784-14-7

1435784-14-7 Structure

1435784-14-7 Structure
IdentificationBack Directory
[Name]

Lometrexol hydrate
[CAS]

1435784-14-7
[Synonyms]

[Molecular Formula]

C21H27N5O7
[MDL Number]

MFCD21608516
[MOL File]

1435784-14-7.mol
[Molecular Weight]

461.48
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 5 mg/ml,DMSO: 20 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Biological Activity]

Lometrexol hydrate (DDATHF hydrate), an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol hydrate can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol hydrate has anticancer activity[1][2].
[storage]

Store at -20°C
[References]

[1]. Xu L, et al. The effect of inhibiting glycinamide ribonucleotide formyl transferase on the development of neural tube in mice. Nutr Metab (Lond). 2016 Aug 23;13(1):56. [2]. Julie L Bronder, et al. Antifolates Targeting Purine Synthesis Allow Entry of Tumor Cells Into S Phase Regardless of p53 Function. Cancer Res. 2002 Sep 15;62(18):5236-41.
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