| Identification | Back Directory | [Name]
5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-N-(2-methyl-1-oxopropyl)guanosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] | [CAS]
144089-97-4 | [Synonyms]
DMT-2FLUORO-DG(IB) AMIDITE
ibu-2'-F-dG Phosphoramidite
2'-F-dG(iBu)-CE Phosphoramidite
DMT-2'-F-dG(iBu)-CE Phosphoramidite
5'-O-DMT-2'-fluoro-N2-isobutyryl-2'-Deoxy-guanosine 3'-CE phosphoramidite
2'-fluoro-N2-isobutyryl-5'-O-(4, 4'-dimethoxytrityl)-2'-deoxyguanosine-3'-CE-Phosphoramidite
5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-N-(2-methyl-1-oxopropyl)guanosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-N-(2-methyl-1-oxopropyl)-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]-6-oxo-3H-purin-2-yl]-2-methylpropanamide | [Molecular Formula]
C44H53FN7O8P | [MDL Number]
MFCD12912415 | [MOL File]
144089-97-4.mol | [Molecular Weight]
857.91 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
DMSO : 100 mg/mL (116.56 mM) | [form ]
powder | [pka]
9.16±0.20(Predicted) | [color ]
white to off-white | [InChIKey]
CFFUQMXILRDKMM-QPYLYBSMNA-N | [SMILES]
C(NC1=NC(=O)C2=C(N1)N([C@H]1[C@H](F)[C@H](OP(OCC)N(C(C)C)C(C#N)(C)C)[C@@H](COC(C3=CC=C(OC)C=C3)(C3=CC=C(OC)C=C3)C3=CC=CC=C3)O1)C=N2)(=O)C(C)C |&1:10,11,13,28,r| |
| Hazard Information | Back Directory | [Description]
DMT-2'-Fluoro-dG(Ib) Phosphoramidite is a 2′Fluoro phosphoramidite that is used to synthesize oligonucleotides that are more thermally stable and provide increased nuclease resistance.
| [Uses]
DMT-2''Fluoro-DG(IB) amidite (CAS# 144089-97-4) is a nucleoside used in the preparation of cyclic dinucleotide compounds, and in the preparation of 4''-C-methoxy-2''-deoxy-2''-fluoro modified ribonucleotides, which improve metabolic stability and elicit efficient RNAi-mediated gene silencing. | [Definition]
The key features of DMT-2'-Fluoro-dG(Ib) Phosphoramidite include, Can be employed together with DNA or RNA phosphoramidites Recommended deprotection conditions are 8 hours at 55 °C using concentrated ammonia solution, or with AMA for 10 minutes at 65 °C Synthesis of 2′Fluoro oligonucleotides is similar to standard DNA synthesis but requires an elongated coupling time (recommended is 3 minutes compared to 90 seconds for DNA monomers) Consistent lot-to-lot high purity and performance Manufactured under a certified ISO 9001 quality system.
| [storage]
4°C, protect from light |
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