| Identification | Back Directory | [Name]
H-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-OH | [CAS]
144189-71-9 | [Synonyms]
Aβ22-35
EDVGSNKGAIIGLM
β-Amyloid 22-35
H-EDVLGSNKGAIIGLM-OH
BETA-AMYLOID (22-35)
AMyloid b-Protein (22-35)
Amyloid β-Protein （22-35）
AMYLOID BETA-PROTEIN (22-35)
Amyloid beta-protein fragment
AMYLOID B-PROTEIN FRAGMENT 22-35
amyloid β-protein fragment 22-35
AMYLOID BETA-PROTEIN FRAGMENT 22-35
Amyloid β-Protein (22-35)/β-Amyloid (22-35)
Amyloid beta-Protein Fragment 22-35 >=95% (HPLC)
GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET
H-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-OH
H-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-OH USP/EP/BP
L-Methionine, L-α-glutamyl-L-α-aspartyl-L-valylglycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl- | [Molecular Formula]
C59H102N16O21S | [MDL Number]
MFCD00236784 | [MOL File]
144189-71-9.mol | [Molecular Weight]
1403.6 |
| Chemical Properties | Back Directory | [Boiling point ]
1805.7±65.0 °C(Predicted) | [density ]
1.289±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
3.24±0.10(Predicted) | [Sequence]
H-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-OH |
| Hazard Information | Back Directory | [Uses]
β-Amyloid 22-35 (Amyloid β-Protein 22-35), the residues 22-35 fragment ofβ-amyloid protein, has a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium. β-Amyloid 22-35 forms aggregates and typical amyloid fibrils resembling those of the β-amyloid protein in neutral buffer solution)[1]. | [Biological Activity]
Has cytotoxic effect on cultured neurons from r at hippocampus in serum free medium. Also forms aggregates and fibrils similar to those of β-amyloid protein in senile plaque cores. | [storage]
Store at -20°C | [References]
[1] Takadera T, et al. Toxic effect of a beta-amyloid peptide (beta 22-35) on the hippocampal neuron and its prevention. Neurosci Lett. 1993 Oct 14;161(1):41-4. DOI:10.1016/0304-3940(93)90135-8
[2] Zhou WW, et al. Decreasing oxidative stress and neuroinflammation with a multifunctional peptide rescues memory deficits in mice with Alzheimer disease. Free Radic Biol Med. 2014;74:50-63. DOI:10.1016/j.freeradbiomed.2014.06.013 |
|
|