| Identification | Back Directory | [Name]
t-butyl acetate-PEG3-CH2COOH | [CAS]
1442466-57-0 | [Synonyms]
HOOCCH2O-PEG3-CH2COOtBu
t-butyl acetate-PEG3-CH2COOH | [Molecular Formula]
C14H26O8 | [MDL Number]
MFCD32862427 | [MOL File]
1442466-57-0.mol | [Molecular Weight]
322.35 |
| Hazard Information | Back Directory | [Biological Activity]
t-Butyl acetate-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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