| Identification | Back Directory | [Name]
VU0469650 | [CAS]
1443748-47-7 | [Synonyms]
VU0469650
CID73755207
VU 0469650 HCl
VU 0469650 hydrochloride
3-[(3R)-3-METHYL-4-[(4-METHYLADAMANTAN-1-YL)CARBONYL]PIPERAZIN-1-YL]PYRIDINE-2-CARBONITRILE
2-Pyridinecarbonitrile, 3-[(3R)-3-methyl-4-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-1-piperazinyl]-
3-[(3R)-3-Methyl-4-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-1-piperazinyl]-2-pyridinecarbonitrile hydrochloride | [Molecular Formula]
C22H28N4O | [MDL Number]
MFCD30182286 | [MOL File]
1443748-47-7.mol | [Molecular Weight]
364.48 |
| Chemical Properties | Back Directory | [Boiling point ]
584.7±50.0 °C(Predicted) | [density ]
1.25±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 100 mM,Ethanol: 50 mM | [form ]
Solid | [pka]
1.42±0.12(Predicted) | [color ]
Off-white to light yellow | [optical activity]
[α]/D -41 to -51°, c =1 in methanol |
| Hazard Information | Back Directory | [Uses]
VU 0469650 Hydrochloride is potent and selective negative allosteric modulators of metabotropic glutamate receptor 1 (mGlu1). | [Biological Activity]
VU0469650 is a brain-penetrantpotent and selective metabotropic glutamate receptor 1 (mGlu1) negative allosteric modulator (NAM). VU0469650 selectively inhibits glu-induced Ca2+ influx in human mGluR1-expressing HEK 293A (EC50 = 99 nM with [Glu] = EC20 for 1.9 minthen EC100 for 1.7 min; inactive against cells expressing human mGlu2-8 at 10 μM) with no affinity toward a panel of 68 clinically relevant GPCRsion channelskinasesand transporters. Prior administration of VU0469650 in mice in vivo (60 mg/kg i.p.) modulates the antipsychotic activity of M4 muscarinic receptor PAM VU0467154 and th at of the M1/M4 agonist xanomeline. | [storage]
Store at +4°C |
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ChemeGen 中国
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18818260767 |
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https://www.chemegen.com |
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4008-099-669 |
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https://www.chemicalbook.com/ShowSupplierProductsList112975/0.htm |
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www.sangon.com |
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