ChemicalBook--->CAS DataBase List--->1448316-08-2

1448316-08-2

1448316-08-2 Structure

1448316-08-2 Structure
IdentificationBack Directory
[Name]

BAY-826 (BAY826)
[CAS]

1448316-08-2
[Synonyms]

BAY-826 (BAY826)
[3-Cyano-5-[[[2,4-dimethyl-5-[6-(3-pyridinyl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl]amino]carbonyl]phenyl]pentafluorosulfur
[Molecular Formula]

C26H19F5N6OS
[MDL Number]

MFCD31657322
[MOL File]

1448316-08-2.mol
[Molecular Weight]

558.53
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[pka]

12.49±0.70(Predicted)
[color ]

White to yellow
Hazard InformationBack Directory
[Description]

BAY-826 is a highly potent, orally available TIE-2-inhibitor which improves tumor control in syngeneic mouse glioma models.
[Definition]

ChEBI: BAY-826 is a secondary carboxamide resulting from the formal condensation of the carboxy group of 3-cyano-5-(pentafluoro-lambda(6)-sulfanyl)benzoic acid with the amino group of 2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]aniline. It is a potent TIE-2 inhibitor (Kd = 1.6 nM) which displays in vivo efficacy in some murine glioma models. It has a role as an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an antineoplastic agent. It is a member of pyridines, an imidazopyrazole, a member of benzamides, a secondary carboxamide, a nitrile, an organofluorine compound and an organosulfur compound.
[storage]

Store at -20°C
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