ChemicalBook--->CAS DataBase List--->144860-70-8

144860-70-8

144860-70-8 Structure

144860-70-8 Structure
IdentificationBack Directory
[Name]

REVEROMYCIN D
[CAS]

144860-70-8
[Synonyms]

REVEROMYCIN D
Butanedioic acid, 1-[(2S,3R,6S,8R,9S)-8-[(2E,4E,6S,7S,8E)-9-carboxy-6-hydroxy-3,7-dimethyl-2,4,8-nonatrien-1-yl]-2-[(1E,3E)-4-carboxy-3-methyl-1,3-butadien-1-yl]-9-methyl-3-pentyl-1,7-dioxaspiro[5.5]undec-3-yl] ester
[Molecular Formula]

C37H54O11
[MDL Number]

MFCD08061900
[MOL File]

144860-70-8.mol
[Molecular Weight]

674.82
Chemical PropertiesBack Directory
[Boiling point ]

855.3±65.0 °C(Predicted)
[density ]

1.20±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

White to tan solid.
[pka]

4.36±0.17(Predicted)
Hazard InformationBack Directory
[Description]

Reveromycin D is a bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells and has pH-dependent antifungal activity against C. albicans (MICs = 2 and >500 μg/ml at pH 3 and 7.4, respectively). Reveromycin D also inhibits proliferation of KB and K562 cells (IC50s = 1.6 and 1.3 μg/ml, respectively).
[Uses]

Reveromycin D is a minor component of the reveromycin complex.
[Uses]

Reveromycin D is the isopentyl analogue and a minor component of the reveromycin complex, isolated from a Streptomyces sp.. Published information on reveromycin D suggests that it is more active than its straight chain analogue, reveromycin C.
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