| Identification | Back Directory | [Name]
UM729 | [CAS]
1448723-60-1 | [Synonyms]
C07
UM729
CS-1240
UM-729;UM 729
UM729 USP/EP/BP
methyl 4-(3-(piperidin-1-yl)propylamino)-9H-pyrimido[4,5-b]indole-7-carboxylate
4-[[3-(1-Piperidinyl)propyl]amino]-9H-pyrimido[4,5-b]indole-7-carboxylic acid methyl ester
9H-Pyrimido[4,5-b]indole-7-carboxylic acid, 4-[[3-(1-piperidinyl)propyl]amino]-, methyl ester | [Molecular Formula]
C20H25N5O2 | [MDL Number]
MFCD28167784 | [MOL File]
1448723-60-1.mol | [Molecular Weight]
367.44 |
| Hazard Information | Back Directory | [Biological Activity]
UM729 is an enhancer of aryl hydrocarbon receptor (AhR) antagonists. | [in vitro]
um729 expands normal hematopoietic stem and progenitor cells (HSPC) in an AhR-independent manner, and UM729 inhibits AML cell differentiation. In 05H163 cells, the addition of UM729 increased CD34+CD15- Number of cells. It can inhibit the differentiation of most AML cells in combination with AhR antagonists. | [in vivo]
In NSG mice, UM729, alone or in combination with SR1, enhanced engraftment but not leukemia stem cell (LSC) frequency distribution. |
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