| Identification | Back Directory | [Name]
Propanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-,1,1-dimethylethyl ester | [CAS]
145119-18-2 | [Synonyms]
Boc-NH-PEG1-C2-Boc
N-Boc-PEG-t-butyl ester
t-Butyl 3-(2-N-Boc-aminoethoxy)propanoate
Propanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-,1,1-dimethylethyl ester | [Molecular Formula]
C14H27NO5 | [MDL Number]
MFCD29764404 | [MOL File]
145119-18-2.mol | [Molecular Weight]
289.37 |
| Hazard Information | Back Directory | [Biological Activity]
N-Boc-PEG-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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