14556-46-8

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14556-46-8 Structure

Identification	Back Directory
[Name] Bupranolol
[CAS] 14556-46-8
[Synonyms] Bupranol Ophtorenin Bupranolol BRN 2272923 Bupranololum KL 255Ophtorenin B 1312; BRN 2272923; BUPRANOLOLUM; KL 255OPHTORENIN 1-(tert-Butylamino)-3-[(6-chloro-m-tolyl)oxy]-2-propanol 1-(tert-Butylamino)-3-(2-chloro-5-methylphenoxy)-2-propanol (S)-1-(tert-Butylamino)-3-(2-chloro-5-methylphenoxy)-2-propanol (2S)-1-(tert-Butylamino)-3-(2-chloro-5-methylphenoxy)-2-propanol 2-Propanol, 1-(tert-butylamino)-3-[(6-chloro-m-tolyl)oxy]- (8CI) 2-Propanol, 1-(2-chloro-5-methylphenoxy)-3-[(1,1-dimethylethyl)amino]- 1-[(2-Chloro-5-methylphenyl)oxy]-3-[(1,1-dimethylethyl)amino]propan-2-ol non-selective,competitive,Adrenergic Receptor,Bupranolol,Inhibitor,intrinsic,sympathomimetic,active,Beta Receptor,inhibit,orally
[Molecular Formula] C14H22ClNO2
[MOL File] 14556-46-8.mol
[Molecular Weight] 271.78

Chemical Properties	Back Directory
[Melting point ] 71-74°C
[storage temp. ] Hygroscopic, Refrigerator, Under Inert Atmosphere
[solubility ] DMSO (Slightly), Methanol (Slightly)
[form ] Solid
[color ] White to Off-White

Hazard Information	Back Directory
[Originator] Betadrenol,Pharma-Schwarz,W. Germany,1969
[Uses] Bupranolol is an antagonist at the cardiostimulatory low-affinity state of b(1)-adrenoceptors and is known to treat hypertension and tachycardia.
[Definition] ChEBI: Bupranolol is an aromatic ether.
[Manufacturing Process] A mixture of 16.3 g of (2-chloro-5-methylphenyl)glycidic ether (from epichlorohydrin and 2-chloro-5-methylphenol) and 6.2 g of t-butylamine in 50 ml of ethanol is heated at reflux for 6 hours. The solvent is removed, the residue is washed with water and then extracted with benzene. The dried extract is evaporated to give 1-t-butylamino-3-(2-chloro-5-methylphenoxy)-2- propanol. Treatment of the free base in benzene solution with dry hydrogen chloride yields the hydrochloride salt.
[Therapeutic Function] Antiarrhythmic
[storage] Store at -20°C

Spectrum Detail	Back Directory
[Spectrum Detail] Bupranolol(14556-46-8)¹HNMR

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