| Identification | Back Directory | [Name]
Bupranolol | [CAS]
14556-46-8 | [Synonyms]
Bupranol
Ophtorenin
Bupranolol
BRN 2272923
Bupranololum
KL 255Ophtorenin
B 1312; BRN 2272923; BUPRANOLOLUM; KL 255OPHTORENIN
1-(tert-Butylamino)-3-[(6-chloro-m-tolyl)oxy]-2-propanol
1-(tert-Butylamino)-3-(2-chloro-5-methylphenoxy)-2-propanol
(S)-1-(tert-Butylamino)-3-(2-chloro-5-methylphenoxy)-2-propanol
(2S)-1-(tert-Butylamino)-3-(2-chloro-5-methylphenoxy)-2-propanol
2-Propanol, 1-(tert-butylamino)-3-[(6-chloro-m-tolyl)oxy]- (8CI)
2-Propanol, 1-(2-chloro-5-methylphenoxy)-3-[(1,1-dimethylethyl)amino]-
1-[(2-Chloro-5-methylphenyl)oxy]-3-[(1,1-dimethylethyl)amino]propan-2-ol
non-selective,competitive,Adrenergic Receptor,Bupranolol,Inhibitor,intrinsic,sympathomimetic,active,Beta Receptor,inhibit,orally | [Molecular Formula]
C14H22ClNO2 | [MOL File]
14556-46-8.mol | [Molecular Weight]
271.78 |
| Chemical Properties | Back Directory | [Melting point ]
71-74°C | [storage temp. ]
Hygroscopic, Refrigerator, Under Inert Atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Originator]
Betadrenol,Pharma-Schwarz,W. Germany,1969 | [Uses]
Bupranolol is an antagonist at the cardiostimulatory low-affinity state of b(1)-adrenoceptors and is known to treat hypertension and tachycardia. | [Definition]
ChEBI: Bupranolol is an aromatic ether. | [Manufacturing Process]
A mixture of 16.3 g of (2-chloro-5-methylphenyl)glycidic ether (from
epichlorohydrin and 2-chloro-5-methylphenol) and 6.2 g of t-butylamine in 50
ml of ethanol is heated at reflux for 6 hours. The solvent is removed, the
residue is washed with water and then extracted with benzene. The dried
extract is evaporated to give 1-t-butylamino-3-(2-chloro-5-methylphenoxy)-2-
propanol. Treatment of the free base in benzene solution with dry hydrogen
chloride yields the hydrochloride salt. | [Therapeutic Function]
Antiarrhythmic | [storage]
Store at -20°C |
|
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Energy Chemical
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http://www.energy-chemical.com |
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cjbscvictory
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http://www.weikeqi-biotech.com/ |
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