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145645-62-1

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145645-62-1 Structure

145645-62-1 Structure
IdentificationBack Directory
[Name]

1,2,5,6-TETRAHYDRO-1-[2-[[(DIPHENYLMETHYLENE)AMINO]OXY]ETHYL]-3-PYRIDINECARBOXYLIC ACID HYDROCHLORIDE
[CAS]

145645-62-1
[Synonyms]

NO-711
NNC 711
NNC711,HCl
NO-711 HYDROCHLORIDE
NNC-711 hydrochloride
YZYRTEYMUTWJPL-UHFFFAOYSA-N
NO-711 HCL POTENT GABA UPTAKE IN
1,2,5,6-Tetrahydro-1-(2-(((diphenylmethylene)amino)oxy]ethyl)-3-pyridinecarboxylicacidhydrochloride
1,2,5,6-TETRAHYDRO-1-[2-[[(DIPHENYLMETHYLENE)AMINO]OXY]ETHYL]-3-PYRIDINECARBOXYLIC ACID HYDROCHLORIDE
1-[2-[[(diphenylmethylene)imino]oxy]ethyl]-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid hydrochloride
1-(2-(((DIPHENYLMETHYLENE)IMINO)OXY)ETHYL)-1,2,5,6-TETRAHYDRO-3-PYRIDINE CARBOXYLIC ACID HYDROCHLORIDE
1-[2-[[(Diphenylmethylene)imino]oxy]ethyl]-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid hydrochloride hydrochloride
[Molecular Formula]

C21H23ClN2O3
[MDL Number]

MFCD00153853
[MOL File]

145645-62-1.mol
[Molecular Weight]

386.87
Chemical PropertiesBack Directory
[storage temp. ]

protect from light
[solubility ]

H2O: ≥10 mg/mL at 60 °C
[form ]

solid
[color ]

off-white
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

NNC 711 is an anticonvulsant agent and a selective GABA uptake inhibitor (1,2).
[Uses]

NO-711 hydrochloride is suitable for use as γ-aminobutyric acid (GABA) transporter-1 (GAT-1) antagonists or GABA uptake inhibitor.
[Biological Activity]

Potent and selective inhibitor of GABA uptake by GAT-1 (IC 50 values are 0.04, 171, 1700 and 622 μ M for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). Anticonvulsant following systemic administration in vivo .
[Biochem/physiol Actions]

NO-711 is a potent and selective GABA uptake inhibitor that crosses the blood-brain barrier.
[storage]

Desiccate at +4°C
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