| Chemical Properties | Back Directory | [Boiling point ]
444.1±45.0 °C(Predicted) | [density ]
1.20±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 56 mg/mL (198.34 mM);Ethanol: 6 mg/mL (21.25 mM) | [form ]
Solid | [pka]
10.92±0.40(Predicted) | [color ]
Off-white to light yellow | [Water Solubility ]
Water: Insoluble |
| Hazard Information | Back Directory | [Biological Activity]
M2912 (MSC2504877) is a very potent TNKS1/TNKS2 inhibitor (IC50=0.6 nM for TNKS1) with exquisite selectivity over other PARP family enzymes and favorable compound properties. This inhibitor potently modulates the Wnt/β-catenin pathway by elevating the levels of axin2 (EC50=17 nM) and tankyrase in DLD1 cells in a dose-dependent manner resulting in reduced cellular Wnt reporter activity. | [References]
[1] Buchstaller HP, et al. J Med Chem. 2021 Jul 22;64(14):10371-10392. |
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| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm |
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