| Identification | Back Directory | [Name]
P1 | [CAS]
1461648-55-4 | [Synonyms]
PDIINP1
PDI-IN-P1
PDI IN P1
PDI inhibitor P1
PDI-inhibitor-P1
PDI IN P1,PDI-IN-P-1
N-[(1,1-Dimethylethoxy)carbonyl]-L-phenylalanyl-O-(ethenylsulfonyl)-N-4-pentyn-1-yl-L-tyrosinamide
L-Tyrosinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl-O-(ethenylsulfonyl)-N-4-pentyn-1-yl- | [Molecular Formula]
C30H37N3O7S | [MDL Number]
MFCD30182261 | [MOL File]
1461648-55-4.mol | [Molecular Weight]
583.7 |
| Hazard Information | Back Directory | [Uses]
P1 is a starting material and useful building block of various pharmaceuticals. | [Enzyme inhibitor]
This cell-permeable PDI inhibitor (FW = 583.70 g/mol; CAS 1461648-55- 4; Soluble to 100 mM in DMSO; N-[(1,1-dimethylethoxy)carbonyl]-Lphenylalanyl-O-(ethenyl-sulfonyl)-N-4-pentyn-1-yl-L-tyrosinamide) targets protein disulfide isomerase (IC50 = 1.7 μM), an enzyme that assists in the folding of cellular proteins within the endoplasmic reticulum of mammalian cells. P1 reduces the proliferation of numerous cancer cell lines, with nominal GI50 values of ～4 μM. PDI binds to the axonal microtubuleassociated protein known as Tau, mainly through its thioredoxin-like catalytic domain, by forming a one-to-one complex that prevents Tau misfolding. | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
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