| Identification | Back Directory | [Name]
beta catenin | [CAS]
146409-33-8 | [Synonyms]
CATNB
CTNB1
CTNNB
CTNNB1
FLJ25606
catenin β
id:ibd2058
wu:fb73e10
beta catenin
Catenin beta-1
Catenin β, GST tagged human
catenin (cadherin-associated protein) β 1
Recombinant Mouse Ctnnb1 Protein, His Tag
ANTI-CTNB1(C-TERMINAL) antibody produced in rabbit
Anti-Catenin-β, N-Terminal antibody produced in rabbit | [MDL Number]
MFCD00282178 |
| Hazard Information | Back Directory | [Uses]
Catenin β, GST tagged human has been used:
- as a component of protein kinase buffer for in vitro kinase assay
- in in vitro?citrullination assay to characterize β-catenin citrullination
- to perform differentiation factor screening
| [General Description]
β-catenins are cytoplasmic proteins that are ubiquitously expressed. These proteins associate with E-cadherin at cellular junctions. CTNNB1 (catenin β-1) belongs to the armadillo family of proteins. This protein possesses a 130 amino acid N-terminal domain, 12 imperfect repeats of 42 amino acids termed arm repeats and a 100 amino acid C-terminal domain. The gene encoding β-catenin is localized on human chromosome 3p22.1. | [Biochem/physiol Actions]
β-catenin interacts with T-cell factor and lymphoid enhancer-binding factor (TCF and LEF) transcription factors and is an essential member of the Wingless-Wnt signal transduction pathway. The adenomatous polyposis coli (APC) tumor-suppressor protein, together with Axin and glycogen synthase kinase 3 β (GSK3β), form a Wnt-regulated signaling complex that mediates phosphorylation-dependent degradation of βcatenin by the proteasome. APC and the Siah-1 E3 ubiquitin-protein ligase-1 mediate a novel β-catenin degradation pathway linking p53 activation to cell cycle control. Activating mutations in the human β-catenin gene have been found in human colon cancer and melanomas. The protein has a role in homeostasis and development. |
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