| Identification | Back Directory | [Name]
4-bromobutyl nitrate | [CAS]
146563-40-8 | [Synonyms]
SKL119
4-bromobutyl nitrate
4-(nitrooxy)butyl bromide
4-Bromo-1-butanol 1-Nitrate
1-Butanol, 4-bromo-, 1-nitrate | [Molecular Formula]
C4H8BrNO3 | [MDL Number]
MFCD27944939 | [MOL File]
146563-40-8.mol | [Molecular Weight]
198.02 |
| Chemical Properties | Back Directory | [storage temp. ]
Refrigerator, under inert atmosphere | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Oil | [color ]
Pale Yellow |
| Hazard Information | Back Directory | [Uses]
4-bromobutyl nitrate is an intermediate in synthesizing Latanoprostene Bunod (L177335). It is a derivative of Latanoprost and is used in the treatment of interocular pressure. | [Preparation]
4-Bromobutyl nitrate is a thermally unstable oily liquid, which is used to obtain nitrooxyalkyl esters of pharmacologically active carboxylic acids (WO 04/020384, WO 04/020385). 4-Bromobutyl nitrate not dissolved in solvents is added to the solution / suspension of pharmacologically active carboxylic acids such as naproxen, ferulic acid, etc. 4-Bromobutyl nitrate is obtained by nitration with a sulfonitizing mixture of 4-bromo-1-hydroxybutane (Chem. Pharm. Bull., 1993, 41, p. 1040). The reaction is carried out by adding 4-bromo-1-hydroxybutane to the crude sulphonating mixture in the absence of solvents or diluents. The reaction is limited to a laboratory scale since the method is potentially explosive due to a sudden increase in temperature and gas production.
https://patents.google.com/patent/RU2388746C2/en |
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