| Identification | Back Directory | [Name]
2-AMINO-3'-HYDROXY-ACETOPHENONE HYDROCHLORIDE | [CAS]
14665-75-9 | [Synonyms]
Phenylephrine Impurity 26
2-AMino-3'-hydroxy-acetophenone HCl
2-amino-1-(3-hydroxy-phenyl)-ethanone
2-AMINO-3'-HYDROXY-ACETOPHENONE HYDROCHLORIDE
2-Amino-1-(3-hydroxyphenyl)ethanone Hydrochloride | [Molecular Formula]
C8H9NO2.ClH | [MDL Number]
MFCD11974302 | [MOL File]
14665-75-9.mol | [Molecular Weight]
187.625 |
| Chemical Properties | Back Directory | [Melting point ]
221–222°C | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly), Water (Slightly) | [form ]
Solid | [color ]
Pale Beige to Brown |
| Hazard Information | Back Directory | [Uses]
2-Amino-3’-hydroxy-acetophenone Hydrochloride is a reactant in the synthesis of TRPM8 modulators. | [Preparation]
Preparation by hydrolysis of m-(benzoyloxy)- a-amino-acetophenone hydrochloride (SM) (m.p. 202–205°) with refluxing 10% hydrochloric acid (quantitative yield), for 2 h (80%); ? with 37% hydrochloric acid in chlorobenzene at 90° for 3 h (90%). SM was obtained by reaction of hexamethylenetetramine with m-(benzoyloxy)- a-bromoacetophenone (m.p. 162°) in ethanol in the presence of 37% hydrochloric acid for 6 h at r.t. (75%). |
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