| Identification | Back Directory | [Name]
1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-9-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl ester | [CAS]
1473403-87-0 | [Synonyms]
MC-SN38
1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-9-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl ester | [Molecular Formula]
C32H31N3O8 | [MOL File]
1473403-87-0.mol | [Molecular Weight]
585.6 |
| Chemical Properties | Back Directory | [Boiling point ]
913.6±65.0 °C(Predicted) | [density ]
1.46±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
9.12±0.40(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Description]
MC-SN38 is a drug-linker conjugate composed of a potent microtubule-disrupting agent SN38 and a non-cleavable MC linker to make antibody drug conjugate (ADC). SN-38, an active metabolite of the Topoisomerase I inhibitor Irinotecan, inhibits DNA synthesis and causes frequent DNA single-strand breaks. |
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