| Identification | Back Directory | [Name]
LEUPEPTIN TRIFLUOROACETATE SALT | [CAS]
147385-61-3 | [Synonyms]
LEUPEPTIN TRIFLUOROACETATE SALT
leupeptintrifluoroacetatesalt90+%
ACETYL-LEU-LEU-ARG-AL TRIFLUOROACETATE SALT
LEUPEPTIN TRIFLUOROACETATE FROM*MICROBIA L SOURCE
Leupeptin trifluoroacetate salt >=90% (HPLC), microbial
Leupeptin trifluoroacetate salt,Acetyl-Leu-Leu-Arg-al trifluoroacetate salt
2-acetamido-N-[1-[[5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methylpentanamide,2,2,2-trifluoroaceticaci | [Molecular Formula]
C22H39F3N6O6 | [MDL Number]
MFCD00133458 | [MOL File]
147385-61-3.mol | [Molecular Weight]
540.58 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
H2O: 10 mM Solutions are stable only a few hours. Stock solutions are stable up to 6 months at −20°C. |
| Hazard Information | Back Directory | [Uses]
Leupeptin Trifluoroacetate is a protease inhibitor, used in the characterization of macroautophagic flux in vivo using leupeptin-based assay. | [Biochem/physiol Actions]
Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.) |
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| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|