| Identification | Back Directory | [Name]
ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID | [CAS]
148796-53-6 | [Synonyms]
HFPA
HYDROXYFARNESYL PHOSPHATE
MONZTFSZTWQCKH-IJFRVEDASA-N
A-hydroxyfarnesylphosphonic acid
α-hydroxy Farnesyl Phosphonic Acid
alpha-Hydroxyfarnesylphosphonic aicd
ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID
ALPHA-HYDROXYFARNESYL PHOSPHONIC ACID ETHANOL SOLUTION
αhydroxy Farnesyl Phosphonic Acid,α hydroxy Farnesyl Phosphonic Acid
(+/-)-1-HYDROXY-3,7,11-TRIMETHYL-2E,6E,10-DODECATRIENE-1-PHOSPHONIC ACID
Phosphonic acid, P-[(2E,6E)-1-hydroxy-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]- | [EINECS(EC#)]
200-578-6 | [Molecular Formula]
C15H27O4P | [MDL Number]
MFCD00216148 | [MOL File]
148796-53-6.mol | [Molecular Weight]
302.35 |
| Hazard Information | Back Directory | [Description]
α-hydroxy Farnesyl phosphonic acid is a nonhydrolyzable analog of farnesyl pyrophosphate which acts as a competitive inhibitor of farnesyl transferase (FTase). At concentrations greater than 1 μM, α-hydroxy farnesyl phosphonic acid inhibits the processing of Ras in Ha-ras-transformed NIH3T3 cells. | [Uses]
α-hydroxy Farnesyl phosphonic acid is a nonhydrolyzable analog of farnesyl pyrophosphate which acts as a competitive inhibitor of farnesyl transferase (FTase). At concentrations greater than 1 μM, α-hydroxy farnesyl phosphonic acid inhibits the processing of Ras in Ha-ras-transformed NIH3T3 cells. | [References]
[1] Gibbs, et al. Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo. J. Biol. Chem. 268(11), 7617-7620 (1993). |
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