| Identification | Back Directory | [Name]
CREBtide | [CAS]
149155-45-3 | [Synonyms]
L-Arginine, L-lysyl-L-arginyl-L-arginyl-L-α-glutamyl-L-isoleucyl-L-leucyl-L-seryl-L-arginyl-L-arginyl-L-prolyl-L-seryl-L-tyrosyl- | [Molecular Formula]
C73H129N29O19 | [MOL File]
149155-45-3.mol | [Molecular Weight]
1716.99 |
| Hazard Information | Back Directory | [Biological Activity]
CREBtide is a synthetic 13 amino acid peptide that acts as a PKA substrate. | [in vitro]
delta-CREB is a spliced variant of cAMP response element binding protein (CREB). CREBtide (KRREILSRRPSYR), a synthetic peptide based on the phosphorylation sequence in delta-CREB. delta-CREB and CREBtide are tested as substrates of cAMP-dependent protein kinase (cAK). The apparent K m of CREBtide phosphorylation by cAK is 3.9 μM, which is 10-fold lower than that of Kemptide (K m =39 μM), the synthetic peptide substrate most often employed for cAK measurement. The V max values are 12.4 mumol/(min.mg) for CREBtide and 9.8 mumol/(min.mg) for Kemptide. The apparent K m of CREBtide phosphorylation by cGMP-dependent protein kinase (cGK) is 2.9 μM and the V max value is 3.2 mumol/(min.mg). Both delta -CREB and CREBtide are phosphorylated at a much slower rate by cGK as compared with cAK, implying that the high cAK/cGK specificity exhibits by delta-CREB is retained by the peptide. | [target]
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| Company Name: |
Ontores Biotech
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0571-88760729 18072970094 |
| Website: |
www.ontoresinc.cn |
| Company Name: |
MedChemExpress
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021-58955995 |
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www.medchemexpress.com |
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