| Identification | Back Directory | [Name]
LOE 908 HYDROCHLORIDE | [CAS]
149759-26-2 | [Synonyms]
LOE 908
Pinokalant
LOE 908 HYDROCHLORIDE
1-Isoquinolineacetamide, 3,4-dihydro-6,7-dimethoxy-α-phenyl-N,N-bis[2-(2,3,4-trimethoxyphenyl)ethyl]-
3,4-Dihydro-6,7-dimethoxy-α-phenyl-N,N-bis[2-(2,3,4-trimethoxyphenyl)ethyl]-1-isoquinolineacetamidehydrochloride | [Molecular Formula]
C41H48N2O9 | [MDL Number]
MFCD09038554 | [MOL File]
149759-26-2.mol | [Molecular Weight]
712.83 |
| Hazard Information | Back Directory | [Uses]
LOE 908 Hydrochloride is a isoquinoline derivative and a cation channel blocker. LOE 908 Hydrochloride is a neuroprotective agent. | [Biological Activity]
Broad spectrum cation channel blocker. Inhibits several cation channels including store-operated calcium channels (SOCs), voltage-operated calcium channels (VOCs), non-selective cation channels (NSCCs), AMPA, NMDA, Na + and K + channels. Neuroprotective; reduces cortical infarct size and improves neurological outcome following middle cerebral artery occlusion. |
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