| Identification | Back Directory | [Name]
17-(DIMETHYLAMINOETHYLAMINO)-17-DEMETHOXYGELDANAMYCIN HCL | [CAS]
150270-08-9 | [Synonyms]
DL 3631
GledanaMycin
Geldanamycin, 4,5-dihydro-
17-(DIMETHYLAMINOETHYLAMINO)-17-DEMETHOXYGELDANAMYCIN HCL | [Molecular Formula]
C29H42N2O9 | [MDL Number]
MFCD08457919 | [MOL File]
150270-08-9.mol | [Molecular Weight]
562.65 |
| Chemical Properties | Back Directory | [Boiling point ]
767.9±60.0 °C(Predicted) | [density ]
1.22±0.1 g/cm3(Predicted) | [RTECS ]
LX8925000 | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml). | [form ]
solid | [pka]
8.88±0.70(Predicted) | [color ]
Purple | [Sensitive ]
Light Sensitive | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| Hazard Information | Back Directory | [Description]
17-DMAG (150270-08-9) is an analog of geldanamycin (Cat.# 10-1084) that displays superior pharmacological properties. 17-DMAG inhibits HSP90 and induces apoptosis in a variety of tumor cell lines. Inhibits angiogenesis. Cell Permeable. | [Definition]
ChEBI: Alvespimycin is a 19-membered macrocyle that is geldanamycin in which the methoxy group attached to the benzoquinone moiety has been replaced by a 2-(N,N-dimethylamino)ethylamino group. It has a role as a Hsp90 inhibitor. It is a secondary amino compound, a tertiary amino compound, an ansamycin, a member of 1,4-benzoquinones and a carbamate ester. It is functionally related to a geldanamycin. | [References]
1) Glaze et al. (2005), Preclinical toxicity of geldanamycin analog 17-(dimethylaminoethylamino)-demethoxygeldanamycin (17-DMAG) in rats and dogs; potential clinical relevance; Cancer Chemother. Pharmacol., 56 637
2) Kaur et al. (2004), Antiangiogenic properties of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin: an orally bioavailable heat shock protein 90 modulator; Clin. Cancer Res., 10 4813 |
|
| Company Name: |
Matrix Scientific
|
| Tel: |
803 788-9494 All other calls |
| Website: |
www.matrixscientific.com |
|