Identification | Back Directory | [Name]
1H-Pyrazole-3-carboxylic acid, 5-hydroxy-1-[3-(trifluoromethyl)phenyl]- | [CAS]
1505579-77-0 | [Synonyms]
ALKBH5 inhibitor 2 ALKBH5 inhibitor 2 (Cpd 20m) 1H-Pyrazole-3-carboxylic acid, 5-hydroxy-1-[3-(trifluoromethyl)phenyl]- | [Molecular Formula]
C11H7F3N2O3 | [MOL File]
1505579-77-0.mol | [Molecular Weight]
272.18 |
Chemical Properties | Back Directory | [Boiling point ]
447.7±45.0 °C(Predicted) | [density ]
1.56±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
3.71±0.10(Predicted) | [color ]
White to off-white |
Hazard Information | Back Directory | [Uses]
ALKBH5-IN-3 (Compound 20m) is a potent and selective ALKBH5 inhibitor, with an IC50 of 21 nM. ALKBH5-IN-3 could efficiently stabilize ALKBH5 in HepG2 cells and increase m6A level in intact cells[1]. | [References]
[1] Fang Z, et, al. Discovery of a potent, selective and cell active inhibitor of m6A demethylase ALKBH5. Eur J Med Chem. 2022 Aug 5:238:114446. DOI:10.1016/j.ejmech.2022.114446 |
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Company Name: |
InvivoChem
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Tel: |
13549236410 |
Website: |
https://www.invivochem.cn/ |
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