ChemicalBook--->CAS DataBase List--->1505579-77-0

1505579-77-0

1505579-77-0 Structure

1505579-77-0 Structure
IdentificationBack Directory
[Name]

1H-Pyrazole-3-carboxylic acid, 5-hydroxy-1-[3-(trifluoromethyl)phenyl]-
[CAS]

1505579-77-0
[Synonyms]

ALKBH5 inhibitor 2
ALKBH5 inhibitor 2 (Cpd 20m)
1H-Pyrazole-3-carboxylic acid, 5-hydroxy-1-[3-(trifluoromethyl)phenyl]-
[Molecular Formula]

C11H7F3N2O3
[MOL File]

1505579-77-0.mol
[Molecular Weight]

272.18
Chemical PropertiesBack Directory
[Boiling point ]

447.7±45.0 °C(Predicted)
[density ]

1.56±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

3.71±0.10(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

ALKBH5-IN-3 (Compound 20m) is a potent and selective ALKBH5 inhibitor, with an IC50 of 21 nM. ALKBH5-IN-3 could efficiently stabilize ALKBH5 in HepG2 cells and increase m6A level in intact cells[1].
[References]

[1] Fang Z, et, al. Discovery of a potent, selective and cell active inhibitor of m6A demethylase ALKBH5. Eur J Med Chem. 2022 Aug 5:238:114446. DOI:10.1016/j.ejmech.2022.114446
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