| Identification | Back Directory | [Name]
5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM | [CAS]
151126-84-0 | [Synonyms]
CL 316243 DISODIUM
CL 316243 disodium s
CL 316243 DISODIUM SALT
5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM
5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylicaciddisodiumsalt
5-[(2R)-2-[[(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO]PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLIC ACID DISODIUM SALT | [Molecular Formula]
C20H18ClNNa2O7 | [MDL Number]
MFCD00907153 | [MOL File]
151126-84-0.mol | [Molecular Weight]
465.79 |
| Chemical Properties | Back Directory | [storage temp. ]
Desiccate at -20°C | [solubility ]
H2O: >10 mg/mL | [form ]
solid | [color ]
white | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months. |
| Hazard Information | Back Directory | [Description]
CL-316243 (151126-84-0) is a potent and selective β3-adrenergic receptor agonist. (EC50= 3 nM) Displays anti-obesity and anti-diabetic effects in mice. It increases brown fat thermogenesis and metabolic rate and decreases blood insulin and glucose levels.1?CL-316243 induces functionally active mitochondrial uncoupling protein (UCP) in white fat.2?Active?in vivo. | [Uses]
CL 316243 Disodium Salt is a potent and highly selective β3-adrenoceptor agonist. | [Biological Activity]
Potent and highly selective β 3 -adrenoceptor agonist (EC 50 = 3 nM); > 10000-fold selective over β 1 and β 2 receptors. Increases brown adipose tissue thermogenesis and metabolic rate, and decreases blood insulin and glucose levels following oral administration in vivo . | [in vitro]
the compound was a potent stimulant of rat adipocyte lipolysis (β3 effect, ec50 = (3.0±0.3) x 10-8 m), had no effect on the rate of contraction of guinea pig atria (β1 effect, ec50 > 10-4 m), and had only a very limited ability to inhibit insulin-stimulated [14c] glucose incorporation into glycogen in isolated rat soleus muacle (β2 effect, ic50 = (3.0±1.0) x 10-5 m) [1]. | [in vivo]
in rat, cl-316,243 treatment resulted in increased growth rates and significant changes in food consumption at the end of the 10-day treatment period. cl-316,243 treatment increased insulin responsiveness and sensitivity in non-insulin-resistant rodent species. the cl-316,243 induced increases in whole-body glucose disposal were due entirely to increases in adipose tissue glucose uptake, while muscle glucose uptake remained unaltered [2]. | [References]
1) Yoshida?et al. (1994),?Anti-obesity and anti-diabetic effects of CL 316,243, a highly specific beta 3-adrenoceptor agonist in yellow KK mice; Life Sci.,?54?491
2) Yoshida?et al. (1998),?β3-Adrenergic agonist induces a functionally active uncoupling protein in fat and slow-twitch muscle fibers; Am. J. Physiol.,?274?E469 |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|