| Identification | Back Directory | [Name]
Sofosbuvir IMpurity | [CAS]
1520010-86-9 | [Synonyms]
Sofosbuvir IMpurity
Sofosbuvir Phosphate Impurity
Sofosbuvir Phenoxyphosphinyl Impurity
L-Alanine, N-(hydroxyphenoxyphosphinyl)-, 1-methylethyl ester | [Molecular Formula]
C12H18NO5P | [MOL File]
1520010-86-9.mol | [Molecular Weight]
287.25 |
| Hazard Information | Back Directory | [Uses]
Isopropyl N-(Hydroxyphenoxyphosphinyl)alaninate Sodium Salt is an impurity of Sofosbuvir (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase. |
|
|