| Identification | Back Directory | [Name]
A 80426 MESYLATE | [CAS]
152148-63-5 | [Synonyms]
A 80426 MESYLATE
6-Benzofuranethanamine, N-methyl-N-[[(1R)-1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl]methyl]-
N-METHYL-N-[[(1R)-1,2,3,4-TETRAHYDRO-5-METHOXY-1-NAPHTHALENYL]METHYL]-6-BENZOFURANETHANAMINE MESYLATE | [Molecular Formula]
C23H27NO2 | [MDL Number]
MFCD10687094 | [MOL File]
152148-63-5.mol | [Molecular Weight]
349.47 |
| Hazard Information | Back Directory | [Uses]
A 80426 Mesylate is used in the synthetic preparation of α2-adrenergic receptor antagonists. | [Biological Activity]
High affinity α 2 -adrenoceptor antagonist and selective 5-HT uptake inhibitor (K i values are 2.01 and 3.77 nM respectively). Displays low affinity at a variety of structurally homologous GPCRs. | [storage]
Store at -20°C | [References]
[1]. hancock aa, buckner sa, oheim kw, et al. a-80426, a potent α2-adrenoceptor antagonist with serotonin uptake blocking activity and putative antidepressant-like effects: i. biochemical profile. drug development research, 1995, 35(4): 237-245.
[2]. aantaa r, marjam?ki a and scheinin m. molecular pharmacology of α2-adrenoceptor subtypes. annals of medicine, 1995, 27(4): 439-449.
[3]. giardina wj, buckner sa, brune me, et al. a-80426, a potent and selective α2-adrenoceptor antagonist with serotonin uptake-blocking activity and putative antidepressant-like effects: ii. pharmacology profile. drug development research, 1995, 35(4): 246-260. |
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