ChemicalBook--->CAS DataBase List--->152239-46-8

152239-46-8

152239-46-8 Structure

152239-46-8 Structure
IdentificationBack Directory
[Name]

SB 204741
[CAS]

152239-46-8
[Synonyms]

SB 204741
1-(1-methyl-5-indolyl)-3-(3-methyl-5-isothiazolyl)urea
3-(3-METHYL-1,2-THIAZOL-5-YL)-1-(1-METHYLINDOL-5-YL)UREA
1-(1-Methyl-1H-indol-5-yl)-3-(3-Methylisothiazol-5-yl)urea
N-(1-METHYL-1H-5-INDOLYL)-N'-(3-METHYL-5-ISOTHIAZOLYL)UREA
N-(1-METHYL-1H-INDOLYL-5-YL)-N''-(3-METHYL-5-ISOTHIAZOLYL)UREA
Urea, N-(1-methyl-1H-indol-5-yl)-N'-(3-methyl-5-isothiazolyl)-
[Molecular Formula]

C14H14N4OS
[MDL Number]

MFCD00923644
[MOL File]

152239-46-8.mol
[Molecular Weight]

286.35
Chemical PropertiesBack Directory
[Melting point ]

>195°C (dec.)
[storage temp. ]

2-8°C
[solubility ]

DMSO: ~18 mg/mL, soluble
[form ]

solid
[color ]

orange
[Stability:]

Hygroscopic
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

36/37/38
[Safety Statements ]

26-36
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

SB 204741 is a potent, selective SR-2B antagonist.
[Definition]

ChEBI: 1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea is a member of ther class of ureas that is urea in which a hydrogen attached to one of the nitrogens has been replaced by an N-methylindol-5-yl group, while a hydrogen attached to the other nitrogen has been replaced by a 3-methyl-1,2-thiazol-5-yl group. It is a potent and selective antagonist for the 5-hydroxytryptamine 2B (5-HT2B) receptor. It has a role as a receptor modulator and a serotonergic antagonist. It is a member of ureas, a member of indoles and a member of 1,2-thiazoles.
[Biological Activity]

Potent and selective 5-HT 2B receptor antagonist (pA 2 = 7.95). Displays ≥ 135-fold selectivity over 5-HT 2C (pK i = 5.82), 5-HT 2A (pK i < 5.2), 5-HT 1A , 1D , 1E , 5-HT 3 and 5-HT 4 receptors.
[storage]

Store at 2-8℃
Spectrum DetailBack Directory
[Spectrum Detail]

SB 204741(152239-46-8)1HNMR
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