| Identification | Back Directory | [Name]
EF-5 | [CAS]
152721-37-4 | [Synonyms]
EF-5
EF5 >=98% (HPLC)
1H-Imidazole-1-acetamide, 2-nitro-N-(2,2,3,3,3-pentafluoropropyl)- | [Molecular Formula]
C8H7F5N4O3 | [MDL Number]
MFCD18450236 | [MOL File]
152721-37-4.mol | [Molecular Weight]
302.16 |
| Chemical Properties | Back Directory | [density ]
1.66±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 125 mg/mL (413.69 mM) | [form ]
Solid | [pka]
12.32±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
EF5 is a 2-nitroimidazole-based hypoxia marker corresponding to a pentafluorinated derivative of the hypoxic cell-radiation sensitizer etanidazole. Under low oxygen (hypoxic) conditionreductive activation of its 2-nitroimidazole moiety leads to enhanced EF5 adduct formation with protein thiols and reduced glutathione. The pentafluorination derivatization substantially decreases the proportion of low molecular weight hydrolytic fragmentation of the adductsmaking EF5 superior to etanidazole when utilized as a hypoxia marker by immunohistological staining. |
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Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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www.sangon.com |
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