| Identification | Back Directory | [Name]
Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE | [CAS]
153088-73-4 | [Synonyms]
Z-D-CH2-DCB
Z-ASP-CH2-DCB
ICE INHIBITOR V
ICE INHIBITOR VI
CASPASE-1 INHIBITOR V
CASPASE-1 INHIBITOR III
Z-ASP-[(2,6-DICHLOROBENZOYL)OXY]METHANE
Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE
N-CBZ-L-ASPARTIC ACID A-(2 6-DICHLORO- &
Z-L-ASP-ALPHA-[(2,6-DICHLOROBENZOYL)OXY]METHANE
N-cbz-L-aspartic acid A-(2,6-dichloro-*benzoyloxy
INTERLEUKIN-1BETA CONVERTING ENZYME INHIBITOR III
Z-L-Asp α-([2,6-dichlorobenzoyloxy]methyl ketone)
N-CBZ-L-aspartic acid alpha-[(2,6-dichlorobenzoyloxy)....
CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE
(BENZYLOXYCARBONYL-L-ASPART-1-YL)[(2,6-DICHLOROBENZOYL)OXY]METHANE
Benzoic acid, 2,6-dichloro-, (3S)-4-carboxy-2-oxo-3-[[(phenylmethoxy)carbonyl]amino]butyl ester | [Molecular Formula]
C20H17Cl2NO7 | [MDL Number]
MFCD00674885 | [MOL File]
153088-73-4.mol | [Molecular Weight]
454.26 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C
| [solubility ]
Soluble in DMSO (up to 25 mg/ml). | [form ]
White to off-white powder. | [color ]
white | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| Hazard Information | Back Directory | [Description]
Z-Asp-CH2-DCB is a peptide originally synthesized for its ability to inactivate the interleukin-1β-converting enzyme, which is the homolog of the C. elegans positive regulator of apoptosis CED-3. Z-Asp-CH2-DCB has been shown to block apoptosis by nonselectively inhibiting caspase activity. At 1-100 μM, it can dose-dependently block the production of IL-1β, TNF-α, IL-6, and IFN-γ by human peripheral blood mononuclear cells as well as inhibit T cell proliferation. | [Uses]
Z-Asp-2,6-dichlorobenzoyloxymethylketone is a broad Caspase Inhibitor. | [References]
1) Dolle et al. (1994) P1 aspartate-based peptide alpha-((2,6-dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1 beta-converting enzyme; J.Med.Chem. 37 563 |
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm |
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