| Identification | Back Directory | [Name]
TGR-1202 (R-enantiomer) | [CAS]
1532533-69-9 | [Synonyms]
RP5264 R-enantiomer
TGR-1202 (R-enantiomer)
Umbralisib (TGR-1202) R-enantiomer
4H-1-Benzopyran-4-one, 2-[(1R)-1-[4-amino-3-[3-fluoro-4-(1-methylethoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-6-fluoro-3-(3-fluorophenyl)- | [Molecular Formula]
C31H24F3N5O3 | [MOL File]
1532533-69-9.mol | [Molecular Weight]
571.55 |
| Chemical Properties | Back Directory | [Boiling point ]
737.4±60.0 °C(Predicted) | [density ]
1.43±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
3.79±0.30(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Description]
Umbralisib R-enantiomer (TGR-1202 R-enantiomer) is a PI3Kδ inhibitor, which is the less active enantiomer of TGR-1202.
PI3Kδ
Umbralisib R-enantiomer (TGR-1202 R-enantiomer) (Formula A) exhibits a 50% inhibitory concentration (IC50) with respect to the δ type PI3-kinase that is at least 20-fold lower than the inhibitor's IC50 with respect to the rest of the other PI3K isoforms (i.e., a, β, and γ)[1]. | [storage]
Store at -20°C | [References]
[1]. Michael Weiss, et al. Combination of anti-cd20 antibody and pi3 kinase selective inhibitor. WO2014071125A1. |
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| Company Name: |
Musechem
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| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
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