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15341-31-8

15341-31-8 Structure

15341-31-8 Structure
IdentificationBack Directory
[Name]

(Z)-α-Nitrostilbene
[CAS]

15341-31-8
[Synonyms]

CID 2818500
(Z)-α-Nitrostilbene
trans-α-Nitrostilbene
CID 2818500 >=98% (HPLC)
[(Z)-2-nitro-2-phenylethenyl]benzene
1,1′-[(1Z)-1-Nitro-1,2-ethenediyl]bis-benzene
Benzene, 1,1'-[(1Z)-1-nitro-1,2-ethenediyl]bis-
[Molecular Formula]

C14H11NO2
[MOL File]

15341-31-8.mol
[Molecular Weight]

225.24
Chemical PropertiesBack Directory
[storage temp. ]

room temp
[solubility ]

DMSO: soluble20mg/mL, clear
[form ]

powder
[color ]

white to beige
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

22-51
[WGK Germany ]

3
Hazard InformationBack Directory
[Biological Activity]

CID 2818500 (trans-α-Nitrostilbene; 1,1μ-[(1Z)-1-Nitro-1,2-ethenediyl]bis-benzene) is a selective inhibitor of Protein Arginine Methyltransferases PRMT1 and PRMT8. PRMT1 is responsible for the majority of arginine methylation in the cell involved in transcriptionchromatin modificationand signal transduction. CID 2818500 has an IC50 values of 11 μM for PRMT1and does not inhibit PRMTs 34and 6although it does inhibit PRMT8. The mechanism is believed to involve a specific S-adenosylmethionine (SAM)-binding cysteine present only in the Type I PRMTs PRMT1 and PRMT8 and absent in other SAM-dependent methyltransferases.
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