| Identification | Back Directory | [Name]
Rapacuronium | [CAS]
156137-99-4 | [Synonyms]
Raplon
Org 9487
Rapacuronium
[(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-3-acetyloxy-10,13-dimethyl-2-piperidin-1-yl-16-(1-prop-2-enylpiperidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl] propanoate | [Molecular Formula]
C37H61N2O4.Br | [MDL Number]
MFCD00870871 | [MOL File]
156137-99-4.mol | [Molecular Weight]
677.803 |
| Chemical Properties | Back Directory | [Melting point ]
184° | [alpha ]
20D -12.7° (c = 1.01 in CHCl3) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 125 mg/mL (184.42 mM) | [form ]
Solid | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
Rapacuronium bromide was introduced in the US as a parenterally
administered adjunct to general anesthesia during surgical procedures. It is a
new steroidal derivative belonging to the same class as vecuronium bromide.
This 2,16-bispiperidinylandrostane derivative can be synthesized in 3 steps from
the 3-hydroxy-androstan-17-one analog and finally quaternized with allyl
bromide. Rapacuronium bromide is a nondepolarizing neuromuscular blocking
drug with a rapid onset and a short duration of action. With a relatively low
potency (ED90 = 1.15 mg/kg), Rapacuronium is expected to be substituted for
the polarizing succinylcholine with very short duration of action. | [Originator]
Akzo Nobel (Netherlands) | [Uses]
Rapacuronium Bromide is an aminosteroidal nondepolarizing neuromuscular blocking agent and was used as a anesthesia. | [Brand name]
Raplon |
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SPIRO PHARMA
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Energy Chemical
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