ChemicalBook--->CAS DataBase List--->1564269-85-7

1564269-85-7

1564269-85-7 Structure

1564269-85-7 Structure
IdentificationBack Directory
[Name]

(R)-BAY1238097
[CAS]

1564269-85-7
[Synonyms]

(R)-BAY1238097
(R)BAY1238097,(R) BAY1238097,(R)-BAY-1238097
3H-2,3-Benzodiazepine-3-carboxamide, 4,5-dihydro-7,8-dimethoxy-N,4-dimethyl-1-[4-(4-methyl-1-piperazinyl)phenyl]-, (4R)-
[Molecular Formula]

C25H33N5O3
[MOL File]

1564269-85-7.mol
[Molecular Weight]

451.56
Chemical PropertiesBack Directory
[density ]

1.22±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 150 mg/mL (332.18 mM);Water : < 0.1 mg/mL (insoluble)
[form ]

Solid
[pka]

15.43±0.60(Predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Description]

(R)-BAY1238097 is the R-isomer with lower activity of BAY1238097. BAY1238097 is a potent and selective inhibitor of BET binding to histones and has strong anti-proliferative activity in different AML (acute myeloid leukemia) and MM (multiple myeloma) models through down-regulation of c-Myc levels and its downstream transcriptome[1][2]. BET[1].

[References]

[1]. Lejeune, P., et al. (2015) Abstract 3524: BAY 1238097, a novel BET inhibitor with strong efficacy in hematological tumor models. Cancer Research, 75(15 Suppl), 884. [2]. Bernasconi E, et al. Preclinical evaluation of the BET bromodomain inhibitor BAY 1238097 for the treatment of lymphoma. Br J Haematol. 2017 Sep;178(6):936-948.

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