| Identification | Back Directory | [Name]
Mito-TEMPO | [CAS]
1569257-94-8 | [Synonyms]
Mito-TEMPO (hydrate)
[2-[(1-$l^{1}-oxidanyl-2,2,6,6-tetramethylpiperidin-4-yl)amino]-2-oxoethyl]-triphenylphosphanium:chloride:hydrate | [Molecular Formula]
C29H37ClN2O3P* | [MOL File]
1569257-94-8.mol | [Molecular Weight]
528.042 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 15 mg/ml; DMSO: 10 mg/ml; Ethanol: 15 mg/ml; PBS (pH 7.2): 5 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
MitoTEMPO is a mitochondria-targeted superoxide dismutase mimetic that possesses superoxide and alkyl radical scavenging properties.1 This compound combines the antioxidant piperidine nitroxide TEMPO with the lipophilic cation triphenylphosphonium, which allows it to pass through lipid bilayers and accumulate in mitochondria.1 Mitochondrial targeting of superoxide scavenging via mitoTEMPO has been examined for potential therapeutic benefit to a variety of mitochondrial dysfunctions arising from excessive reactive oxygen species.2,3,4 | [References]
1. Dikalov, S. Cross talk between mitochondria and NADPH oxidases Free Radic. Biol. Med. 51(7),1289-1301(2011).
2. Liang, H.L., Arsenault, J., Mortensen, J., et al. Partial attenuation of cytotoxicity and apoptosis by SOD1 in ischemic renal epithelial cells Apoptosis 14(10),1176-1189(2009).
3. Dikalova, A.E., Bikineyeva, A.T., Budzyn, K., et al. Therapeutic targeting of mitochondrial superoxide in hypertension Circ. Res. 107(1),106-116(2010).
4. Liang, H.L., Sedlic, F., Bosnjak, Z., et al. SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after ATP depletion recovery Free Radic. Biol. Med. 49(10),1550-1560(2010). |
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