ChemicalBook--->CAS DataBase List--->159857-79-1

159857-79-1

159857-79-1 Structure

159857-79-1 Structure
IdentificationBack Directory
[Name]

Val-cit-PAB-OH
[CAS]

159857-79-1
[Synonyms]

EOS-61316
al-Cit-PAB-OH
Val-cit-PAB-OH
NH2-Val-Cit-PAB
(D)-VAL-CIT-PAB
L-Valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide
L-Ornithinamide, L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-
(S)-2-((R)-2-amino-3-methylbutanamido)-N-(4-(hydroxymethyl)phenyl)-5-ureidopentanamide
(S)-2-((S)-2-amino-3-methylbutanamido)-N-(4-(hydroxymethyl)phenyl)-5-ureidopentanamide
[EINECS(EC#)]

826-617-2
[Molecular Formula]

C18H29N5O4
[MDL Number]

MFCD22381209
[MOL File]

159857-79-1.mol
[Molecular Weight]

379.45
Chemical PropertiesBack Directory
[Melting point ]

168 °C(dec.)
[Boiling point ]

715.0±60.0 °C(Predicted)
[density ]

1.243±0.06 g/cm3(Predicted)
[storage temp. ]

Keep in dark place,Sealed in dry,2-8°C
[solubility ]

DMF: 10 mg/ml; DMSO: 10 mg/ml; PBS (pH 7.2): 1 mg/ml
[form ]

powder to crystal
[pka]

13.75±0.46(Predicted)
[color ]

White to Almost white
Safety DataBack Directory
[HS Code ]

2924.29.7790
Hazard InformationBack Directory
[Description]

Val-Cit-PAB-OH is a peptide cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). The Val-Cit will specifically be cleaved by Cathepsin B.
[Uses]

Val-cit-PAB-OH acts as a reagent in the preparation of cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy, preparation of monomethylvaline derivative conjugates with ligands and antibodies for cancer treatment.
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