Identification | Back Directory | [Name]
Val-cit-PAB-OH | [CAS]
159857-79-1 | [Synonyms]
EOS-61316 al-Cit-PAB-OH Val-cit-PAB-OH NH2-Val-Cit-PAB (D)-VAL-CIT-PAB L-Valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide L-Ornithinamide, L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- (S)-2-((R)-2-amino-3-methylbutanamido)-N-(4-(hydroxymethyl)phenyl)-5-ureidopentanamide (S)-2-((S)-2-amino-3-methylbutanamido)-N-(4-(hydroxymethyl)phenyl)-5-ureidopentanamide | [EINECS(EC#)]
826-617-2 | [Molecular Formula]
C18H29N5O4 | [MDL Number]
MFCD22381209 | [MOL File]
159857-79-1.mol | [Molecular Weight]
379.45 |
Chemical Properties | Back Directory | [Melting point ]
168 °C(dec.) | [Boiling point ]
715.0±60.0 °C(Predicted) | [density ]
1.243±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
DMF: 10 mg/ml; DMSO: 10 mg/ml; PBS (pH 7.2): 1 mg/ml | [form ]
powder to crystal | [pka]
13.75±0.46(Predicted) | [color ]
White to Almost white |
Hazard Information | Back Directory | [Description]
Val-Cit-PAB-OH is a peptide cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). The Val-Cit will specifically be cleaved by Cathepsin B. | [Uses]
Val-cit-PAB-OH acts as a reagent in the preparation of cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy, preparation of monomethylvaline derivative conjugates with ligands and antibodies for cancer treatment. |
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