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1599432-34-4

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1599432-34-4 Structure

1599432-34-4 Structure
IdentificationBack Directory
[Name]

Maleimide-NH-PEG6-CH2CH2COOPFP Ester
[CAS]

1599432-34-4
[Synonyms]

Mal-NH-PEG6-CH2CH2COOPFP ester
Maleimide-NH-PEG6-CH2CH2COOPFP Ester
[Molecular Formula]

C28H35F5N2O11
[MDL Number]

MFCD34470032
[MOL File]

1599432-34-4.mol
[Molecular Weight]

670.58
Hazard InformationBack Directory
[Biological Activity]

Mal-NH-PEG6-CH2CH2COOPFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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