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1610882-30-8

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1610882-30-8 Structure

1610882-30-8 Structure
IdentificationBack Directory
[Name]

TCS-OX2-29 HCl
[CAS]

1610882-30-8
[Synonyms]

TCS-OX2-29 HCl
TCSOX229 HCl,TCS-OX-2-29 HCl,TCS OX2 29 HCl
(2S)-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3,3-dimethyl-2-(pyridin-4-ylmethylamino)butan-1-one:hydrochloride
[Molecular Formula]

C23H32ClN3O3
[MDL Number]

MFCD12828766
[MOL File]

1610882-30-8.mol
[Molecular Weight]

433.98
Chemical PropertiesBack Directory
[solubility ]

DMF: 30 mg/ml; DMSO: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
[form ]

A crystalline solid
[color ]

White
Hazard InformationBack Directory
[Description]

Orexin receptors R1 (OX1R) and OX2R mediate the action of the neuropeptides orexin A and orexin B. TCX-OX2-29 is an antagonist of OX2R (pKi = 7.5) that exhibits >250-fold selectivity for hOX2R compared with hOX1R (IC50s = 40 nM and >10,000 nM, respectively). It blocks the inhibitory action of orexin A on forskolin-induced cAMP formation.
[storage]

+4°C
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