| Identification | Back Directory | [Name]
Z-Vad-fmk, non-methylated | [CAS]
161401-82-7 | [Synonyms]
Z-VAD-FMK, Free Acid
Z-VAD-FMK (Caspase Inhibitor VI)
Z-VAD(OH)-FMK (Caspase Inhibitor VI)
Z-VAL-ALA-ASP-(OH)-FLUOROMETHYL KETONE
Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem
Carbobenzyloxy-Val-Ala-Asp-alpha-fluoromethylketone
L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-1-(carboxymethyl)-3-fluoro-2-oxopropyl]-
L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[1-(carboxymethyl)-3-fluoro-2-oxopropyl]-, (S)-
L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-1-(carboxymethyl)-3-fluoro-2-oxopropyl]- (9ci) | [Molecular Formula]
C21H28FN3O7 | [MOL File]
161401-82-7.mol | [Molecular Weight]
453.46 |
| Chemical Properties | Back Directory | [Boiling point ]
758.0±60.0 °C(Predicted) | [density ]
1.260±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO:5.0(Max Conc. mg/mL);11.0(Max Conc. mM) | [form ]
Off-white solid | [pka]
3.91±0.19(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Description]
Z-VAD(OH)-FMK is an irreversible tripeptide inhibitor of all caspases. This non-methylated form is useful in studies involving recombinant, isolated, or purified enzymes. Unlike the methylated form, Z-VAD(OMe)-FMK , this compound does not require pretreatment with esterases prior to in vitro use. | [General Description]
An irreversible general caspase inhibitor. Useful for studies involving recombinant, isolated, and purified caspase enzymes. Unlike Caspase Inhibitor I (Cat. No. 627610), this inhibitor does not require pretreatment with esterase for in vitro studies. A 10 mM (1 mg/221 μl) solution of Caspase Inhibitor VI (Cat. No. 219011) in DMSO is also available. | [Biochem/physiol Actions]
Product does not compete with ATP. |
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