| Identification | Back Directory | [Name]
4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(2H-tetrazol-5-yl)butyl]-piperidine | [CAS]
162640-98-4 | [Synonyms]
AT 56
CS-1414
AT56/AT-56
AT 56, >=98%
4-Dibenzo[a,d] cyclohepten-5-ylidene-1-[4-(1H-tetrazol-5-yl) butyl] piperdine
4-Dibenzo[a,d]cyclohepten-5-ylidene-1-[4-(2H-tetrazol-5-yl)-butyl]-piperidine
4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(1H-tetrazol-5-yl)butyl]piperidine
4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(2H-tetrazol-5-yl)butyl]-piperidine
Piperidine, 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(2H-tetrazol-5-yl)butyl]-
4-(DIBENZO[1,2-A:1',2'-E][7]ANNULEN-11-YLIDENE)-1-[4-(2H-TETRAZOL-5-YL)BUTYL]PIPERIDINE | [EINECS(EC#)]
200-256-5 | [Molecular Formula]
C25H27N5 | [MDL Number]
MFCD18086874 | [MOL File]
162640-98-4.mol | [Molecular Weight]
397.52 |
| Chemical Properties | Back Directory | [Boiling point ]
620.4±65.0 °C(Predicted) | [density ]
1.216±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [solubility ]
DMSO: soluble10mg/mL, clear | [form ]
powder | [pka]
4.99±0.10(Predicted) | [color ]
white to beige | [InChIKey]
LQNGMDUIRLSESZ-UHFFFAOYSA-N | [SMILES]
N1(CCCCC2=NNN=N2)CC/C(=C2/C3=CC=CC=C3C=CC3=CC=CC=C3/2)/CC1 |
| Hazard Information | Back Directory | [Uses]
AT-56 is an orally active inhibitor of Lipocalin-type prostaglandin D synthase. | [in vitro]
AT-56 (1-30 μM; 10 minutes) dose-dependently inhibits the production of PGD2 in L-PGDS-expressing human medulloblastoma TE-671 cells with an IC50 of about 3 μM.
| [in vivo]
AT-56 (1-30 mg/kg; p.o.) suppresses the PGD2 production in the stab-wounded brain.
AT-56 (1-10 mg/kg; p.o.) suppresses the L-PGDS-mediated allergic airway inflammation in mice.
AT-56 (10 mg/kg; p.o.) exhibits Cmax (2.15 μg/ml), half-life (1.71 h) and high oral bioavailability (82%). | [storage]
Store at -20°C |
|
|