| Identification | Back Directory | [Name]
LY-3177833 | [CAS]
1627696-51-8 | [Synonyms]
CS-2783
LY-3177833
LY 3177833;LY-3177833
(R)-3-(5-fluoropyrimidin-4-yl)-3-methyl-6-(1H-pyrazol-4-yl)isoindolin-1-one
1H-Isoindol-1-one, 3-(5-fluoro-4-pyrimidinyl)-2,3-dihydro-3-methyl-6-(1H-pyrazol-4-yl)-, (3R)- | [Molecular Formula]
C16H12FN5O | [MDL Number]
MFCD30533280 | [MOL File]
1627696-51-8.mol | [Molecular Weight]
309.3 |
| Chemical Properties | Back Directory | [Boiling point ]
660.7±55.0 °C(Predicted) | [density ]
1.398±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:30.0(Max Conc. mg/mL);96.99(Max Conc. mM) | [form ]
A crystalline solid | [pka]
11.67±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
LY3177833 is an orally bioavailable inhibitor of Cdc7 kinase (IC50 = 3.3 nM for ADP production in an enzyme assay). It inhibits phosphorylation of MCM2-S53 in H1299 cells (IC50 = 0.29 μM). LY3177833 reduces tumor growth in an SW620 human colorectal adenocarcinoma mouse xenograft model when administered at doses of 10, 20, and 30 mg/kg twice per day. |
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