| Identification | Back Directory | [Name]
MI-136 | [CAS]
1628316-74-4 | [Synonyms]
MI-136
CS-2162
MI136;MI 136
HY-19319 (MI 136
MI-136;HY-19319 (MI 136; MI136);
5-((4-((6-(2,2,2-Trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-in
5-[[4-[[6-(2,2,2-Trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-1H-indole-2-carbonitrile
1H-Indole-2-carbonitrile, 5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]- | [Molecular Formula]
C23H21F3N6S | [MDL Number]
MFCD28506294 | [MOL File]
1628316-74-4.mol | [Molecular Weight]
470.51 |
| Chemical Properties | Back Directory | [Boiling point ]
654.9±55.0 °C(Predicted) | [density ]
1.45±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: 10 mg/ml | [form ]
A crystalline solid | [pka]
14.20±0.30(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
MI-136 is an inhibitor of the menin-MLL interaction (IC50 = 31 nM; Kd = 23.6 nM). By blocking MLL recruitment predominantly at the level of the menin-MLL interaction, it can inhibit androgen receptor (AR)-mediated transcription. At 40 mg/kg, MI-136 has been shown to block AR signaling, inhibiting the growth of castration-resistant tumors in mice. |
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