ChemicalBook--->CAS DataBase List--->1638211-05-8

1638211-05-8

1638211-05-8 Structure

1638211-05-8 Structure
IdentificationBack Directory
[Name]

TH287 (hydrochloride)
[CAS]

1638211-05-8
[Synonyms]

CS-2086
TH287 HCl
[Molecular Formula]

C11H11Cl3N4
[MDL Number]

MFCD28127273
[MOL File]

1638211-05-8.mol
[Molecular Weight]

305.59
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
Hazard InformationBack Directory
[Description]

TH287 hydrochloride is a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM, less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.IC50 value: 0.8 nM [1]Target: MTH1 inhibitorTH287 is considered a new target for cancer therapy. TH287 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family. TH287 has been shown to selectively kill a variety of cancer cell lines, but is rapidly metablized, so not as useful for in vivo studies.

[storage]

Store at -20°C
[References]

[1]. Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508(7495):215-21.

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