| Identification | Back Directory | [Name]
MYK-461 (SAR-439152) | [CAS]
1642288-47-8 | [Synonyms]
SAR439152
SAR-439152
SAR 439152
Mavacamten (MYK-461
MYK-461 (SAR-439152)
MYK-461 - Mavacamten | SAR439152
SAR-439152; SAR 439152; SAR439152; MYK-461; MYK 461; MYK461; MAVACAMTEN
2,4(1H,3H)-Pyrimidinedione, 3-(1-methylethyl)-6-[[(1S)-1-phenylethyl]amino]-
6-([(1S)-1-phenylethyl]amino)-3-(propan-2-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione | [Molecular Formula]
C15H19N3O2 | [MDL Number]
MFCD31746877 | [MOL File]
1642288-47-8.mol | [Molecular Weight]
273.33 |
| Chemical Properties | Back Directory | [density ]
1.19±0.1 g/cm3(Predicted) | [solubility ]
insoluble in H2O; ≥11.32 mg/mL in EtOH with ultrasonic; ≥13.65 mg/mL in DMSO | [form ]
solid | [pka]
8.83±0.40(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C15H19N3O2/c1-10(2)18-14(19)9-13(17-15(18)20)16-11(3)12-7-5-4-6-8-12/h4-11,16H,1-3H3,(H,17,20)/t11-/m0/s1 | [InChIKey]
RLCLASQCAPXVLM-NSHDSACASA-N | [SMILES]
C1(=O)NC(N[C@H](C2=CC=CC=C2)C)=CC(=O)N1C(C)C |
| Hazard Information | Back Directory | [Description]
MYK-461 is a mechanistically novel small molecule that acts on the sarcolemma to specifically inhibit contractility and has been proposed as a treatment for HCM. | [Uses]
MYK-461 is a drug used to treat obstructive hypertrophic cardiomyopathy as a cardiac myosin inhibitor. | [Mechanism of action]
Mavacamten is thought to work by reducing cardiac muscle contractility by inhibiting excessive myosin-actin cross-bridge formation that results in hypercontractility, left ventricular hypertrophy and reduced compliance. In clinical and preclinical studies, it has consistently reduced biomarkers of cardiac wall stress, lessened excessive cardiac contractility, and increased diastolic compliance. | [Side effects]
Common side effects include:Dizziness, fainting, Incidence not known, Chest pain or tightness, decreased urine output, dilated neck veins, irregular breathing, irregular heartbeat, swelling of the face, fingers, feet, or lower legs, trouble breathing, unusual tiredness or weakness and weight gain. |
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