| Identification | Back Directory | [Name]
PDE1-IN-1 (phosphate) | [CAS]
1642303-38-5 | [Synonyms]
ITI214
ITI-214 phosphate
PDE1-IN-1 (phosphate)
ITI-214 phosphate salt
ITI-214; ITI 214; ITI214; ITI-214 PHOSPHATE SALT.
(6AR,9aS)-2-(4-(6-fluoropyridin-2-yl)benzyl)-5-methyl-3-(phenylamino)-5,6a,7,8,9,9a-hexahydrocyclopenta[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one phosphate | [Molecular Formula]
C29H29FN7O5P | [MDL Number]
MFCD28385868 | [MOL File]
1642303-38-5.mol | [Molecular Weight]
605.57 |
| Hazard Information | Back Directory | [Description]
ITI214 is an inhibitor of phosphodiesterase 1 (PDE1; Ki = 0.058 nM). It is selective for PDE1 over PDE2A, -3B, -4A, -5A, -6, -7B, -8A, -9A, -10A, and -11A (Kis = 0.16-18 μM). ITI214 (3 and 6 mg/kg) enhances novel object recognition in rats. It increases prefrontal cortex cAMP and cGMP levels in mice when administered at a dose of 50 mg/kg. ITI214 (0.1, 3, and 10 mg/kg) reverses MK-801-induced decreases in spontaneous alteration in the T-maze continuous alternation task in mice. |
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| Company Name: |
Musechem
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+1-800-259-7612 |
| Website: |
www.musechem.com |
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